王永明 研究员
复旦大学生命科学学院
研究员，博士生导师，2015年国家青年千人获得者。1997-2001年就读兰州大学生命科学学院并获得学士学位，2001-2004年就读东北师范大学生命科学学院并获得硕士学位，2005-2010年在德国马克斯-德尔布吕克分子医学中心（MDC）做博士生研究，并获得柏林自由大学博士学位。2010-2013年在斯坦福大学医学院从事博士后研究。2013年至今历任复旦大学生命科学学院青年研究员、研究员。主要从事基因编辑技术的开发和应用研究，先后在Circulation Research,Journal of the American College of Cardiology, Nucleic Acids Research和PlOS Genetics等杂志发表重要文章。2015年，入选中组部青年千人计划。
代表性成果：
1. Wang YM*, Pryputniewicz-Dobrinska D*, Nagy EE*, Kaufman CD*, Singh M, Yant S, Wang J, Dalda A, Kay MA, Ivics Z, Izsvak Z. Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition. Nucleic Acids Research. 2017 Jan; 45(1):311-326 (IF: 8.2).
2. Qi JL*, Dong ZJ*, Shi YW, Wang X, Qin YY, Wang YM, Liu D. NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish. Cell Research. 2016 Dec; 26(12): 1349-1352 (IF: 14.8).
3. He ZH*, Sun S*, Waqas M, Zhang XL, Qian FP, Cheng C, Zhang MS, Zhang SS, Wang YM, Tang ML, Li HW, Chai RJ. Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro. Scientific Reports. 2016 Jul; 13;6: 29621 (IF: 5.2).
4. Wang YM*, Liang P*, Lan F*, Wu HD*, Lisowski L, Gu MX, Hu SJ, Kay MA, Urnov FD, Shinnawi R, Gold J, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing. Journal of the American College of Cardiology. 2014 Aug; 64 (5): 451-459 (IF: 14.1).
5. Wang YM*, Wang JC*, Chen JX, Deveraj A, Selbach M, Ivics Z and Izsvak Z. Suicidal autointegration of Sleeping Beauty and piggyback transposons in eukaryotic cells. PlOS Genetics. 2014 Mar; 10(3): e10043103 (IF: 8.5).
6. Liang P*, Lan F*, Lee AS*, Gong TY, Sanchez-Freire V, Wang YM, Nguyen PK, Bers D, Robbins RC, Wu JC. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease specific patterns of cardiotoxicity. Circulation. 2013 Apr; 127(16): 1677-91 (IF: 15.2).
7. Hu SJ, Wilson KD, Ghosh Z, Han L, Wang YM, Lan F, Ransohoff KJ, Wu JC. MicroRNA-302 increases reprogramming efficiency via repression of NR2F2. Stem Cells. 2013 Feb; 31(2):259-68 (IF: 7.7).
8. Lan F*, Lee AS*, Liang P*, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang YM, Sun N, Abilez OJ, Hu SJ, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC. Abnormal Calcium Handling Properties Underlie Pathogenesis of Familial Hypertrophic Cardiomyopathy in Patient-Specific Induced Pluripotent Stem Cells. Cell Stem Cell. 2013 Jan; 12(1) 101-13. (IF: 25.3).
9. Wang YM Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC*.Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nuclease for cellular imaging. Circulation Research. 111(12): 1494-503 （IF: 11.9）.
10. Nguyen PK, Lan F, Wang YM, Wu JC. Imaging: Guiding the clinical translation of cardiac stem cell therapy. Circulation Research. 2011;109:962-979 (IF: 9.5).
11. Wang YM, Liska F*, Gosele C, Sedova L, Kren V, Krenova D, Ivics Z, Hubner N, and Izsvak Z. A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains. Genome Research. 2010 Jan; 20(1) 19-27. (IF: 14.4).